Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

Hypersensitivity Responses in Compromised Humoral and Delayed-Type

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses.

CCR6 expression in dendritic, T, and B cells suggests that this beta-chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses. Here we demonstrate that CCR6-/- mice have underdeveloped Peyer's patches, in which the myeloid CD11b+ CD11c+ dendritic-cell subset is not present in the subepithelial d...

Enhanced humoral antibody production and delayed type hypersensitivity response in mice by Lactobacillus casei.

Antibody titers against Pseudomonas aeruginosa in sera from mice were markedly elevated by pre-injection of Lactobacillus casei. The number of plaque-forming cells against sheep red blood cells ( SRBC) in the spleen of mice pretreated with L. casei was highter than those in the controls. L. casei also enhanced the delayed type hypersensitivity response against SRBC in mice. Therefore, it was re...

Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18.

Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishma...

Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin.

Leukocyte rolling and emigration in response to inflammatory stimuli appears to involve both E-selectin- and P-selectin-dependent adhesion, which suggests that these molecules have overlapping functions. To clarify their relative contributions in chronic inflammation, we examined delayed-type contact hypersensitivity (DTH) responses in P-selectin, E-selectin, and E-/P-selectin-deficient mice. O...